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In animal trials, CBD has shown to reduce seizure severity and lethality, decreasing the percentage of animals that experience the most severe tonic-clonic seizures (Jones 2012).
Clinical research trials in humans are just in their infancy, but anecdotal evidence to the wonders of CBD on epilepsy is abundant (Porter 2013). There are numerous social media groups formed to share advice on using CBD to counteract seizure activity. Some claim that CBD has transformed their lives, reducing or completely stopping seizure activity that once dominated their day, and allowing them to wean off other medications with powerful negative side effects. Many of the traditional epilepsy medications have adverse effects that are said to have as much impact on the patient’s ability to enjoy life as the seizures themselves. CBD is generally well tolerated, with low toxicity and few side effects. Surveys suggest that CBD may even have beneficial effects on cognition and mood, with many parents reporting that their children had better sleep, increased alertness, and a better mood when taking CBD. CBD and other cannabinoids present a potentially life-changing option for anticonvulsants without debilitating side effects.
Alger, Bradley. “Seizing an opportunity for the endocannabinoid system.” Epilepsy Curr, 2014: 272-276.
B Porter, C Jacobson. “Report of a parent survey of cannabidiol-enriched cannabis use in pedatric treatment-resistant epilepsy.” Epilespy and Behaviour, 2013: 4. Foundation, The Epilepsy. What is Epilepsy. http://www.epilepsy.com/learn/epilepsy-101/what-epilepsy, Epilepsy Foundation, 2014.
Jones, Glyn, Akiyama, Hill, Hill, Weston, Burnett, Yamasaki, Stephens, Whalley, Williams. “Cannabidiol exerts anti-convulant effects in animal models of temporal lobe and partial seizures.” Seizure, 2012: 344-352.
Szaflarski JP, Bebin EM. “Cannabis, cannabidiol, and epilepsy– from receptors to clinical response.” Epilepsy Behav., 2014: 277-82. Welty T, Luebke A, Gidal B. “Cannabidiol: Promise and pitfalls.” Epilepsy Curr., 2014: 250-252.