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Epilepsy & Seizures | Quadratum Hemp | Hemp-Based CBD Products

Epilepsy & Seizures

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November 26, 2016
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Can CBD help with epilepsy and seizures?

Epilepsy is a chronic disorder that affects nearly 1 in 26 people and causes recurrent, unprovoked seizures in the body. Although a seizure may affect any part of the body, it is the brain that produces the electrical events that actually cause the seizure (The Epilepsy Foundation 2014). Scientific data supports the role of the endocannabinoid system or ECS in seizure generation, maintenance, and control in animal models of epilepsy (Szaflarski 2014). When activated, ECS receptors can inhibit the transmission of certain synapses (the junction across which a nerve impulse passes), which are known to modulate seizure activity (Welty 2014). Endocannabinoids influence epileptic activity by inhibiting synaptic transmission. The ECS is not a fixed entity and can be both enhanced and reduced. Epileptic seizures alter the way the ECS and their receptors work, changing the way the ECS sends its signals (Alger 2014). Cannabinoids, such as CBD, have been viewed as “circuit breakers” because they are said to work as a powerful anticonvulsant able to halt seizure activity.

In animal trials, CBD has shown to reduce seizure severity and lethality, decreasing the percentage of animals that experience the most severe tonic-clonic seizures (Jones 2012).

Clinical research trials in humans are just in their infancy, but anecdotal evidence to the wonders of CBD on epilepsy is abundant (Porter 2013). There are numerous social media groups formed to share advice on using CBD to counteract seizure activity. Some claim that CBD has transformed their lives, reducing or completely stopping seizure activity that once dominated their day, and allowing them to wean off other medications with powerful negative side effects. Many of the traditional epilepsy medications have adverse effects that are said to have as much impact on the patient’s ability to enjoy life as the seizures themselves. CBD is generally well tolerated, with low toxicity and few side effects. Surveys suggest that CBD may even have beneficial effects on cognition and mood, with many parents reporting that their children had better sleep, increased alertness, and a better mood when taking CBD. CBD and other cannabinoids present a potentially life-changing option for anticonvulsants without debilitating side effects.

Works Cited

Alger, Bradley. “Seizing an opportunity for the endocannabinoid system.” Epilepsy Curr, 2014: 272-276.

B Porter, C Jacobson. “Report of a parent survey of cannabidiol-enriched cannabis use in pedatric treatment-resistant epilepsy.” Epilespy and Behaviour, 2013: 4. Foundation, The Epilepsy. What is Epilepsy., Epilepsy Foundation, 2014.

Jones, Glyn, Akiyama, Hill, Hill, Weston, Burnett, Yamasaki, Stephens, Whalley, Williams. “Cannabidiol exerts anti-convulant effects in animal models of temporal lobe and partial seizures.” Seizure, 2012: 344-352.

Szaflarski JP, Bebin EM. “Cannabis, cannabidiol, and epilepsy– from receptors to clinical response.” Epilepsy Behav., 2014: 277-82. Welty T, Luebke A, Gidal B. “Cannabidiol: Promise and pitfalls.” Epilepsy Curr., 2014: 250-252.


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