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Treating Rheumatoid Arthritis with CBD Oil | Quadratum Hemp | Hemp-Based CBD Products

Treating Rheumatoid Arthritis with CBD Oil

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November 27, 2016
MS and Cannabis
November 27, 2016

Treating Rheumatoid Arthritis with CBD Oil

Any acute or chronic inflammation of a joint is considered arthritis, though it comes in two main forms: rheumatoid arthritis and osteoarthritis. Osteoarthritis is the most common form of arthritis, found primarily among the elderly, in joints with severe wear and tear, or bone loss. Rheumatoid arthritis (RA) is an auto-immune disease, where the body’s immune system attacks synovial membranes on the joints as it would a foreign invader like viruses or bacteria, eventually destroying cartilage and even eroding bone.

Both conditions involve inflammation at the site of arthritis which can cause pain and even structural changes on those joints.  Maintaining healthy bone involves keeping inflammation, which can create extra pressure on these joints, to a minimum. An ideal pharmaceutical would alleviate pain, inflammation, and also help keep bones strong and healthy.

Cannabinoids, such as CBD oil, not only act as an anti-inflammatory, and help to reduce pain, but they also are showing tremendous potential in modulating bone growth and maintenance (Bab and Zimmer, 2008). In fact, research has shown that transgenic mice that are missing either the CB1 or the CB2 cannabinoid receptor develop osteoporosis much more quickly than normal mice, and those missing both cannabinoid receptors have extremely weak bones (Karsak et al, 2005). New studies are also showing that mutations in cannabinoid receptors correlate with bone disease (Karsak et al., 2009), and that CBD oil has been found to suppress the immune response of a disease that resembles arthritis in mice and rats, protecting their joints and improving their condition (Malfait, 2000; Costa 2004).

When cannabis is metabolized by the body, it creates a number of related chemicals that act upon the endocannabinoid system, which regulates bodily functions, resulting in anti-inflammatory and pain-relieving effects. Certain fats found in cannabis, known as sterols, can also help suppress the immune response, as well as alleviate pain and inflammation. Studies have shown that rheumatoid arthritis patients who ingest CBD oils were found to have improved mobility, less inflammation in their joints, and reduced morning stiffness, as well as being able to reduce the use of other NSAIDs commonly used to treat the condition.

Not only is cannabis like a wonder-cocktail of benefits for rheumatoid arthritis, but it is also relatively non-toxic, and is tolerated with few, if any, mild side-effects. This is unlike traditional treatments for rheumatoid arthritis, which can commonly cause ulcers, kidney and liver toxicity, depressed respiration, or worse; and often times produce tremendous physical dependence. In fact, cannabis has been used for thousands of years for rheumatism, and is even recognized in Chinese texts from 2,000 BC as “undo(ing) rheumatism” (Zurier, 1998).

Do you use CBD oil for your arthritis? Do you find it helpful? Send your story to, and you might be featured on our website!

Works Cited

Bab I and Zimmer A (2008). Cannabinoid receptors and the regulation of bone mass. Br J Pharmacol 153(2):182-188.

Costa B et al (2004). Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naunyn Schmiedebergs Arch Pharmacol. Mar;369(3):294-9. Epub 2004 Feb 12.
Karsak M, et al (2005). Cannabinoid receptor type 2 gene is associated with human osteoporosis. Hum Mol Genet 14(22):3389-3396.

Karsak M, et al (2009). The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. Hum Genet.

Malfait AM et al (2000) .The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. Aug 15 97(17):9561-6.

Zurier RB et al (1998). Dimethylheptyl-THC-11 Oic Acid: A Nonpsychoactive Antiinflammatory Agent with a Cannabinoid Template Structure. ARTHRITIS AND RHEUMATISM January; volume 41, number 1, pages 163-170.


  1. Hollie says:

    What is the daily recommended dosage for RA of CBD oil ?

    • admin says:

      There are no clear dosing guidelines since there have not been any clinical studies evaluating dosing and efficacy of CBD for RA. Current customers experiencing relief from RA are using a combination of the CBD Balm with anywhere from 25mg – 50mg of CBD by mouth daily. My mom actually uses the Balm only and is able to close her hand into a fist when she does, but she says pain relief is better when she combines the balm with one capsule of CBD in the morning and another one at night. This is consistent with what other customers have been saying. I hope this is helpful, and please let us know if you have any other questions!

      I also copied this message into an email for you.

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